Our Research

Ted Rogers Centre for Heart Research: Cardiac Precision Medicine Program

The Cardiac Precision Medicine Program was built on the premise that understanding the genetic basis of heart failure will allow us to develop medicines that are targeted to the unique type of heart failure, making them safer and more effective. Learn more through the video below.

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PRecIsion Medicine in CardiomyopathY (PRIMaCY)

Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death in adolescents and young adults. Despite the availability of implantable cardioverter-defibrillators (ICD) as a life-saving intervention, the lack of precision in predicting sudden death risk hampers timely ICDs in at-risk patients resulting in deaths that could have been prevented.

PRIMaCY has developed an eHealth clinical decision support tool that generates an individualized 5-year risk prediction for sudden death for each patient. The primary goal is to implement the PRIMaCY tool in hospital information systems for use by physicians as a point of care tool, to evaluate the effectiveness of the tool in adherence to clinical practice guidelines, and to evaluate how it influences patient/family counseling.

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PeRsOnalized Genomics For CongEnital HEart Disease (PROCEED)

Congenital heart disease (CHD) is the leading cause of newborn deaths. Its genetic cause remains elusive in 80% cases. We will use whole genome sequencing to explore the human genome to find gene defects that cause CHD – tetralogy of Fallot (TOF) and transposition of the great arteries (TGA), and determine how these gene defects predict severity of heart disease and outcomes.

The ability to individualize risk prediction based on genotype will help personalize reproductive counselling and help personalize management of CHD families. Genetic based prediction of outcomes can inform timing and type of fetal and postnatal interventions.

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Early Diagnosis of Patients at Risk for Heart Failure Using Genome-Based Diagnostics

We developed an automated pipeline to interrogate a patient’s whole genome sequencing (WGS) for disease-causing and disease-modifying variants in both coding- (exome) as well as non-coding- (regulome) regions. By combining genomic and myocardial expression data and high-throughput functional validation of variants in regulatory regions using human hiPSC-derived cardiomyocytes, we are developing a first-of-its-kind human cardiac atlas of functioning regulatory regions of the genome important in childhood heart disease. Compared to conventional genetic testing, genome sequencing of over 300 cardiomyopathy cases from our biobank enabled us to identify the genetic cause in twice as many families.

Early Biomarker-Based Diagnosis of Patients at Risk for Arrhythmogenic Cardiomyopathy

Arrhythmogenic ventricular cardiomyopathy (AVC) is a leading cause of HF and sudden cardiac death (SCD). We discovered a novel antibody, anti-desmoglein-2, in the blood stream that can diagnose 95% of patients with this condition before it manifests clinically. The findings are being externally validated. This will lead to the development of a new clinical blood test for AVC, which will enable early interventions to prevent sudden death and heart failure.

Precision Therapeutics for Cardiomyopathy

Myosin variants are the leading genetic cause of cardiomyopathies for which there are no effective therapies. Using iPSCs from patients with myosin variants in our biobank, we generated diseased and gene-corrected cardiomyocytes to model disease and test targeted therapies. We found that a myosin-targeted compound is effective at rescuing disease phenotype in childhood cardiomyopathy caused by these variants. Through ongoing discussion with industry partners, our findings will inform a first in pediatric trial of myosin-targeted drugs, and also identify genetic responders who are likely to benefit from these drugs. By choosing the right drug for the right patient, we will avoid futile therapies, reduce heart failure progression and ultimately the need for heart transplants.

National Biobank Sites and International Collaborations

In The Media

Please also see Recent Highlights for more!

New AHA/ACC guidelines for hypertrophic cardiomyopathy

November 2020

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Precision Child Health: Transforming the Future for Kids with Heart Disease

Annual Report 2019-2020

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Ted Rogers Centre for heart research celebrates fifth anniversary

November 2019

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Why we must screen early in life for hypertrophic cardiomyopathy

August 2019

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Trans-atlantic partnership seeks answers for cyanotic heart disease

April 2019

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High-quality stem cells enable researchers to better study almost any disease

December 2019

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Preventing tragedy in cardiomyopathy

January 2019

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